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The Expression of Vesicular Glutamate Transporter 1 (VGLUT1) in the Rat Larynx and Implications for Laryngeal Proprioception by Victoria X. Yu; Ignacio Hernández-Morato; Susan Brenner-Morton; Michael J. Pitman is a scholarly article available to read on EtoBox.

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ABSTRACT Proprioception plays a crucial role in laryngeal function. Further, dysfunctional proprioception likely contributes to disorders such as laryngeal dystonia, dysphagia and vocal fold paresis. Despite this, the physiology of laryngeal proprioception is not well-understood. Controversy remains over whether canonical proprioceptive organs, like muscle spindles (MS) even exist in the intrinsic laryngeal muscles (ILM). Vesicular Glutamate Transporter 1 (VGLUT1) expression has been described in the sensory afferents of MS. This study’s primary aim is to determine whether the ILM contain MS using VGLUT1. This is a novel approach, as prior studies have relied on morphology and myosin composition to study this question. Secondarily, we describe the pattern of VGLUT1 expression in the rat larynx, Larynges of 62 Sprague-Dawley rats distributed across 5 age groups (P3, P8, P11, P14-15, and adult), were sectioned and immunostained for VGLUT1 and beta-tubulin III. Other markers (S46, GNAT3, PLCβ2, S100b, CGRP) were used to further characterize identified afferent innervation. Of 62 rats, MS were identified in the lateral thyroarytenoid muscles of just three P8 rats, and no golgi tendon o

Author

Victoria X. Yu; Ignacio Hernández-Morato; Susan Brenner-Morton; Michael J. Pitman

Published

2023

Language

EN