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Can I read The Treatment of Multiple Sclerosis with Inosine on EtoBox?
The Treatment of Multiple Sclerosis with Inosine by Clyde E. Markowitz; Sergei Spitsin; Vanessa Zimmerman; Dina Jacobs; Jayaram K. Udupa; D. Craig Hooper; Hilary Koprowski is a Medicine article available to read on EtoBox.
What is The Treatment of Multiple Sclerosis with Inosine about?
Objective: The objective of this study is to evaluate the safety and tolerability of inosine in patients with relapsing-remitting multiple sclerosis (RRMS). The secondary objectives are to assess the effects of inosine administration on serum urate (UA) levels, the progression of neurologic disability, the cumulative number of new, active lesions on magnetic resonance imaging (MRI), and changes in serum levels for markers of inflammation. Design: Oral administration of inosine was used to raise serum levels of the natural peroxynitrite scavenger UA in 16 patients with RRMS during a 1-year randomized, double-blind trial. Outcome measures: The endpoints studied were relapse rate, disability assessed by the Kurtzke Expanded Disability Status Scale (EDSS), MRI, and analysis of serum levels of nitrotyrosine, and oxidative and proinflammatory makers. Results: Increased serum UA levels correlated with a significant decrease in the number of gadoliniumenhanced lesions and improved EDSS. A number of MRI intensity-based parameters were altered by inosine treatment, in certain cases correlating with changes in serum UA levels. In a patient with low serum UA and high lesion activity, raising U
Who reads The Treatment of Multiple Sclerosis with Inosine?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Clyde E. Markowitz; Sergei Spitsin; Vanessa Zimmerman; Dina Jacobs; Jayaram K. Udupa; D. Craig Hooper; Hilary Koprowski
- Publisher
- Mary Ann Liebert Inc
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)