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Immune-related Adverse Events as Potential Surrogates of Immune Checkpoint Inhibitors’ Efficacy: a Systematic Review and Meta-analysis of Randomized Studies by V. Amoroso; F. Gallo; A. Alberti; D. Paloschi; W. Ferrari Bravo; A. Esposito; D. Cosentini; S. Grisanti; R. Pedersini; F. Petrelli; A. Berruti is a Medicine article available to read on EtoBox.
What is Immune-related Adverse Events as Potential Surrogates of Immune Checkpoint Inhibitors’ Efficacy: a Systematic Review and Meta-analysis of Randomized Studies about?
## Background Immune-related adverse events (irAEs) are frequently reported during immune checkpoint inhibitor (ICI) therapy and are associated with long-term outcomes. It is unknown if the irAE occurrence is a valid surrogate of ICIs’ efficacy. ## Methods We identified articles reporting the results of randomized trials of experimental ICI therapy in solid tumors with a systematic search. The control arms could be placebo, cytotoxic/targeted therapy, or ICI therapy. We extracted the hazard ratios for overall survival (OS) with the number of OS events per arm and the number and percentages of overall and specific irAEs of grade 1-2 and grade 3-4 per arm. We estimated the treatment effect on the potential surrogate outcome with the odds ratio of the irAE rate between the experimental and the control arm. The statistical analysis consisted of weighted linear regression on a logarithmic scale between treatment effects on irAE rate and treatment effects on OS. ## Results Sixty-two randomized trials were included for a total of 79 contrasts and 42 247 patients. The analyses found no significant association between the treatment effects for overall grade 1-2 or grade 3-4 irAE rates or sp
Who reads Immune-related Adverse Events as Potential Surrogates of Immune Checkpoint Inhibitors’ Efficacy: a Systematic Review and Meta-analysis of Randomized Studies?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- V. Amoroso; F. Gallo; A. Alberti; D. Paloschi; W. Ferrari Bravo; A. Esposito; D. Cosentini; S. Grisanti; R. Pedersini; F. Petrelli; A. Berruti
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)