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IL-17 aggravates renal injury by promoting podocyte injury in children with primary nephrotic syndrome by Shubo Zhai; Baichao Sun; Yan Zhang; Lengyue Zhao; Li Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Primary nephrotic syndrome (PNS) is the most common chronic kidney disease in childhood, where podocyte injury is a key factor in the occurrence of kidney disease. In the present study, the expression of IL-17 in renal tissues of patients with PNS and its relationship with podocyte injury were examined. Reverse transcription-quantitative PCR (RT-qPCR), western blot analysis and immunochemistry were used to measure the expression of IL-17 in renal biopsies of patients with ONS, including 9 patients with minimal change nephrotic syndrome (MCNS), 15 patients with mesangial proliferative glomerulonephritis (MsPGN) and 9 patients with focal segmental glomerulosclerosis (FSGS), in addition to 15 normal kidney tissues. IL-17 was found to be highly expressed in the renal tissues from patients with PNS, with the highest expression levels found in tissues from patients with FSGS and the lowest in those from MCNS. A negative correlation was observed between the levels of IL-17 mRNA and PCX mRNA in renal tissues, whereas a positive correlation between IL-17 mRNA levels and the number of urinary podocytes in patients with PNS was found. __In vitro__, IL-17 induced podocyte apoptosis and reduced

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Author

Shubo Zhai; Baichao Sun; Yan Zhang; Lengyue Zhao; Li Zhang

Publisher

Spandidos Publications

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)