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Can I read Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1 on EtoBox?
Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1 by Dafne C. A. Quixabeira; Victor Cervera-Carrascon; Joao M. Santos; James H.A. Clubb; Tatiana V. Kudling; Saru Basnet; Camilla Heiniö; Susanna Grönberg-Vähä-Koskela; Marjukka Anttila; Riikka Havunen; Anna Kanerva; Akseli Hemminki is a Immunology and Microbiology article available to read on EtoBox.
What is Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1 about?
## ABSTRACT Intratumoral immunotherapies are entering clinical use but concerns remain regarding their effects on non-injected tumors. Here, we studied the impact of local treatment with an adenovirus coding for TNFa and IL-2 on systemic antitumor response in animals receiving aPD-1 (anti-programmed cell death protein 1) therapy. Using bilateral murine melanoma models, we tested systemic tumor response to combined therapy with anti-PD-1 and an adenovirus coding for TNFa and IL-2 (“virus”). Virus was given intratumorally (to one of the two tumors only) and aPD-1 monoclonal antibody systemically. We evaluated both tumors’ response to treatment, overall survival, metastasis development, and immunological mechanisms involved with response. Consistent tumor control was observed in both injected and non-injected tumors, including complete response in all treated animals receiving aPD-1+ virus therapy. Mechanistically, virus injections enabled potent effector lymphocyte response locally, with systemic effects in non-injected tumors facilitated by aPD-1 treatment. Moreover, adenovirus therapy demonstrated immunological memory formation. Virus therapy was effective in preventing metastasis
Who reads Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Dafne C. A. Quixabeira; Victor Cervera-Carrascon; Joao M. Santos; James H.A. Clubb; Tatiana V. Kudling; Saru Basnet; Camilla Heiniö; Susanna Grönberg-Vähä-Koskela; Marjukka Anttila; Riikka Havunen; Anna Kanerva; Akseli Hemminki
- Publisher
- Informa UK Limited
- Published
- 2022
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)