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Can I read Local Irradiation in Combination with Bevacizumab Enhances Radiation Control of Bone Destruction and Cancer‐induced Pain in a Model of Bone Metastases on EtoBox?
Local Irradiation in Combination with Bevacizumab Enhances Radiation Control of Bone Destruction and Cancer‐induced Pain in a Model of Bone Metastases by Pawel Zwolak; Arkadiusz Z. Dudek; Vidya D. Bodempudi; Julia Nguyen; Robert P. Hebbel; Nathan J. Gallus; Marna E. Ericson; Michael J. Goblirsch; Denis R. Clohisy is a Medicine article available to read on EtoBox.
What is Local Irradiation in Combination with Bevacizumab Enhances Radiation Control of Bone Destruction and Cancer‐induced Pain in a Model of Bone Metastases about?
## Abstract Skeletal metastases are a major source of morbidity for cancer patients. The purpose of this study was to evaluate the effects of megavoltage irradiation and antiangiogenic therapy on metastatic bone cancer. A tumor xenograft model was prepared in C3H/Scid mice using 4T1 murine breast carcinoma cells. Twenty‐eight mice bearing tumors were treated with either bevacizumab (15 mg/kg), local megavoltage irradiation (30 Gy in 1 fraction), combination of bevacizumab and local megavoltage irradiation or physiologic saline solution (control group). Tumor area, bone destruction, tumor microvessel density, pain‐associated behaviors and expression of substance P were assessed. Combined modality treatment reduced the frequency of pain‐associated behaviors, decreased levels of nociceptive protein expression in the spinal cord, maintained cortical integrity and decreased the density of microvessels as compared to single modality treatments. We conclude that concurrent antiangiogenic therapy and localized radiotherapy for the treatment of bone metastases warrants further evaluation in human clinical trials. © 2007 Wiley‐Liss, Inc.
Who reads Local Irradiation in Combination with Bevacizumab Enhances Radiation Control of Bone Destruction and Cancer‐induced Pain in a Model of Bone Metastases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Pawel Zwolak; Arkadiusz Z. Dudek; Vidya D. Bodempudi; Julia Nguyen; Robert P. Hebbel; Nathan J. Gallus; Marna E. Ericson; Michael J. Goblirsch; Denis R. Clohisy
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)