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Simultaneous Determination of Mecamylamine, Nicotine, and Cotinine in Plasma by Gas Chromatography-mass Spectrometry by Peyton Jacob III; Sylvia Wu; Lisa Yu; Neal L Benowitz is a Chemistry article available to read on EtoBox.

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The nicotine receptor antagonist mecamylamine has been shown to increase the efficacy of transdermal nicotine as a pharmacotherapy for tobacco addiction. A product for simultaneous transdermal administration of nicotine and mecamylamine is undergoing clinical trials. In order to carry out pharmacokinetic studies, quantitation of low nanogram per milliliter levels of mecamylamine and nicotine was required. This paper describes a method for simultaneous determination of mecamylamine, nicotine, and the nicotine metabolite, cotinine, in human plasma using gas chromatography-mass spectrometry (GC-MS). Limits of quantitation for mecamylamine, nicotine and cotinine are 2, 1 and 2 ng/ml, respectively.

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Author

Peyton Jacob III; Sylvia Wu; Lisa Yu; Neal L Benowitz

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)

Published

2000

Language

EN

Field

Chemistry (Physical Sciences)