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Expression of CD44 variant proteins in adenocarcinoma of Barrett's esophagus and its relation to prognosis by Thomas C. Böttger; Valentina Youssef; Phillip Dutkowski; Hans Maschek; Walpurga Brenner; Theo Junginger is a Medicine article available to read on EtoBox.
What is Expression of CD44 variant proteins in adenocarcinoma of Barrett's esophagus and its relation to prognosis about?
## BACKGROUND. None of the commonly used staging criteria accurately determine the prognosis of a patient with adenocarcinoma of Barrett's esophagus. The authors therefore assessed the expression pattern and prognostic impact of CD44 standard and CD44 isoforms CD44v4, v5,v6,v7, and v10 in adenocarcinoma of Barrett's esophagus. ## METHODS. Specimens from 41 patients with adenocarcinoma of Barrett's esophagus who underwent esophageal resection were embedded in paraffin and studied immunohistochemically to determine the expression of CD44 splice variants. Histomorphologic parameters and survival time were not known at the time of the investigation. ## RESULTS. Correlations between favorable clinical or histomorphologic parameters and CD44s or any of the split variants could not be established. Down-regulation of CD44s and the split variant v10 was significantly correlated with pT classification. Furthermore, down-regulation of CD44v10 and up-regulation of CD44v7 were significantly correlated with ploidy. There was a significant correlation between CD44s and split variants in tumorous and nontumorous tissue from the same patient. Downregulation of CD44s and CD44v4 had a significant inf
Who reads Expression of CD44 variant proteins in adenocarcinoma of Barrett's esophagus and its relation to prognosis?
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- Author
- Thomas C. Böttger; Valentina Youssef; Phillip Dutkowski; Hans Maschek; Walpurga Brenner; Theo Junginger
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)