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Sympathetic Nerve Traffic Overactivity in Chronic Kidney Disease: a Systematic Review and Meta-analysis by Guido Grassi; Annalisa Biffi; Gino Seravalle; Silvio Bertoli; Flavio Airoldi; Giovanni Corrao; Anna Pisano; Francesca Mallamaci; Giuseppe Mancia; Carmine Zoccali is a Medicine article available to read on EtoBox.

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## Background: Studies based on microneurographic sympathetic nerve activity (msna) recordings have shown that the sympathetic system is overactivated in chronic kidney disease (ckd) patients but the relationship between msna and renal function and other risk factors has not been systematically reviewed in this population. ## Design and measurements: This meta-analysis compares msna in cardiovascular complications-free ckd patients (n = 638) and healthy individuals (n = 372) and assesses the relationship of msna with the egfr, age, bmi and hemodynamic variables. ## Results: In a global analysis, msna was higher in ckd patients than in healthy control individuals (p < 0.001). the difference in msna between patients and healthy individuals was more marked in end-stage kidney diseases patients than in stage 3a 3b ckd patients (p < 0.001). in an analysis combining patients and healthy individuals, msna rose gradually across progressively lower egfr categories (p < 0.01). in separate meta-regression analyses in ckd patients and in healthy individuals, msna associated directly with age (ckd: r = 0.57, p = 0.022; healthy individuals: r = 0.71, p = 0.031) and with the bmi (r = 0.75, p = 0.

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Author

Guido Grassi; Annalisa Biffi; Gino Seravalle; Silvio Bertoli; Flavio Airoldi; Giovanni Corrao; Anna Pisano; Francesca Mallamaci; Giuseppe Mancia; Carmine Zoccali

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN

Field

Medicine (Health Sciences)