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Expression of plasma soluble CR1 and leukocyte surface CR1 in patients with glomerulonephritis by B. Sivasankar; Sadia Ayub; S.C. Tiwari; L.M. Srivastava; Nibhriti Das is a Immunology and Microbiology article available to read on EtoBox.

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Complement deficiency in humans predisposes to severe SLE. We have studied the development of accelerated nephrotoxic nephritis in complement-deficient mice. Glomerulonephritis was induced by immunisation with 200pg rabbit IgG in Freund's complete adjuvant i/p and 7 days later, i/v administration of nephrotoxic globulin (Img). Clq-/-, Bf/CZ-I-and Clq/Bf/CZ-/mice were studied. Animals (7-I2 per group) of mixed (129/SVxC57BL/6) genetic background were compared. Renal histology (day 4) showed mild proliferative changes in wildtype (WT), and Bf/C2-/-animals, but severe glomerular thrombosis in Clq-/-and Clq/Bf/CZ-/-mice. Experiments were also performed in mice of C57BLi6 background (n=9 per group). At day 1 I, mice had proliferative nephritis with significantly more neutrophils (median I per glomerular cross section compared to 0.14 (p< 0.05)), and macrophages (5.4 vs 2.7) in Clq-i-than WT mice (p< 0.05). In addition, by quantitative immunofluorescence, Clq-i-mice had more glomerular IgG2a (median 42 arbitrary fluoresence units v 19) and IgG3 (57 vs 31), but not IgG2b (70 v 86) than WT mice (~~0.05 for IgG2a and IgG3). Electron microscopy showed findings similar to human lupus nephriti

Who reads Expression of plasma soluble CR1 and leukocyte surface CR1 in patients with glomerulonephritis?

Author

B. Sivasankar; Sadia Ayub; S.C. Tiwari; L.M. Srivastava; Nibhriti Das

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0162-3109)

Published

2000

Language

EN

Field

Immunology and Microbiology (Life Sciences)