Can I read Angiostatic effects of Brazilian green propolis and its chemical constituents on EtoBox?

Angiostatic effects of Brazilian green propolis and its chemical constituents by Yuichi Chikaraishi; Hiroshi Izuta; Masamitsu Shimazawa; Satoshi Mishima; Hideaki Hara is a Medicine article available to read on EtoBox.

What is Angiostatic effects of Brazilian green propolis and its chemical constituents about?

## Abstract Propolis, a resinous substance collected by honeybees from various plant sources, has several pharmacological actions, such as anti‐tumor and anti‐inflammatory effects. The aim of this study was to evaluate the anti‐angiogenic effects of a water extract of Brazilian green propolis (WEP) and its constituents, caffeoylquinic acid derivatives, against angiogenic processes in human umbilical vein endothelial cells (HUVECs) __in vitro__. We also examined the anti‐angiogenic effects of WEP against retinal neovascularization in a murine oxygen‐induced retinopathy model __in vivo__. WEP and its constituents significantly suppressed vascular endothelial growth factor (VEGF)‐induced HUVEC proliferation, migration, and tube formation __in vitro__. WEP and its caffeoylquinic acid derivatives suppressed VEGF‐stimulated phosphorylation of mitogen‐activated protein kinase in HUVECs (__versus__ VEGF alone). Moreover, WEP (300 mg/kg/day, subcutaneously for 5 days) significantly suppressed retinal neovascularization in the murine oxygen‐induced retinopathy model. These data indicate that (i) WEP has angiostatic effects against angiogenic processes __in vitro__ and in an __in vivo__ model

Who reads Angiostatic effects of Brazilian green propolis and its chemical constituents?

Author

Yuichi Chikaraishi; Hiroshi Izuta; Masamitsu Shimazawa; Satoshi Mishima; Hideaki Hara

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1613-4125)

Published

2010

Language

EN

Field

Medicine (Health Sciences)