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An overview on prostate-specific membrane antigen uptake in malignancies other than prostate cancer: A pictorial essay by Esmail Jafari; Hojjat Ahmadzadehfar; Habibollah Dadgar; Majid Assadi is a Medicine article available to read on EtoBox.

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Prostate-specific membrane antigen (PSMA) is a Type II transmembrane glycoprotein which is extremely overexpressed in prostate cancer epithelial cells. Recently, PSMA-targeted small molecule labeled with ^68^Ga and ^99m^Tc allowed precise molecular imaging of prostate cancer and PSMA-targeted small molecule labeled with 177Lu leads to the development of radionuclide-targeted therapy of prostate cancer. Despite its name, it has been shown that PSMA has been expressed in several malignancies which can be due to significant neovascularization. Present pictorial assay reports the nonspecific tracer uptake in some malignancies during ^68^Ga-PSMA positron-emission tomography/computed tomography imaging and ^99m^Tc-PSMA scintigraphy.

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Author

Esmail Jafari; Hojjat Ahmadzadehfar; Habibollah Dadgar; Majid Assadi

Published

2020

Language

EN

Field

Medicine (Health Sciences)