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Deregulation of microRNA-181c in cerebrospinal fluid of patients with clinically isolated syndrome is associated with early conversion to relapsing–remitting multiple sclerosis by Jonas Ahlbrecht; Filippo Martino; Refik Pul; Thomas Skripuletz; Kurt-Wolfram Sühs; Celina Schauerte; Özlem Yildiz; Corinna Trebst; Lars Tasto; Sabrina Thum; Angelika Pfanne; Romy Roesler; Florian Lauda; Michael Hecker; Uwe K Zettl; Hayrettin Tumani; Thomas Thum; Martin Stangel is a Medicine article available to read on EtoBox.

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## Background: MiRNA-181c, miRNA-633 and miRNA-922 have been reported to be deregulated in multiple sclerosis. ## Objectives: To investigate the association between miRNA-181c, miRNA-633 and miRNA-922 and conversion from clinically isolated syndrome (CIS) to relapsing–remitting multiple sclerosis (RRMS); and to compare microRNAs in cerebrospinal fluid (CSF) and serum with regard to dysfunction of the blood–CSF barrier. ## Methods: CSF and serum miRNA-181c, miRNA-633 and miRNA-922 were retrospectively determined by quantitative real-time polymerase chain reaction in CIS patients with (CIS-RRMS) and without (CIS-CIS) conversion to RRMS within 1 year. ## Results: Thirty of 58 CIS patients developed RRMS. Cerebrospinal fluid miRNA-922, serum miRNA-922 and cerebrospinal fluid miRNA-181c were significantly higher in CIS-RRMS compared to CIS-CIS ( P=0.027, P=0.048, P=0.029, respectively). High levels of cerebrospinal fluid miRNA-181c were independently associated with conversion from CIS to RRMS in multivariate Cox regression analysis (hazard ratio 2.99, 95% confidence interval 1.41–6.34, P=0.005). A combination of high cerebrospinal fluid miRNA-181c, younger age and more than nine lesion

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Author

Jonas Ahlbrecht; Filippo Martino; Refik Pul; Thomas Skripuletz; Kurt-Wolfram Sühs; Celina Schauerte; Özlem Yildiz; Corinna Trebst; Lars Tasto; Sabrina Thum; Angelika Pfanne; Romy Roesler; Florian Lauda; Michael Hecker; Uwe K Zettl; Hayrettin Tumani; Thomas Thum; Martin Stangel

Publisher

SAGE Publications

Published

2015

Language

EN

Field

Medicine (Health Sciences)