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Effects of Cadmium on Formation of the Ventral Body Wall in Chick Embryos and Their Prevention by Zinc Pretreatment by Jennifer Thompson; John Bannigan is a Medicine article available to read on EtoBox.

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## Abstract ## Background Cadmium (Cd) is an established experimental teratogen whose effects can be reversed by pretreatment with zinc. Mesodermal development is a frequently reported target for Cd teratogenicity. The aim of this study was to examine the mechanisms of Cd induced body wall defects in chick embryos. ## Methods Chick embryos in shell‐less culture were treated with 50 μl of cadmium acetate (8.9 × 10^−5^ M Cd^2+^) at 60‐hr incubation (H.‐H. stages 16–17). Controls received equimolar sodium acetate. Other embryos were treated with various concentrations of zinc acetate and then with Cd or NaAc 1 hrs later. Development was evaluated 48 hrs later. Resin‐embedded 1‐μm sections were examined at earlier stages. ## Results Cd caused embryolethality (35%), ventral body wall defect with malpositioned lower limbs (40%), and weight reduction in survivors. After 4‐hr treatment with Cd, breakdown of junctions between peridermal cells with rounding up and desquamation occurred. Shape changes were also seen in the basal layer of the ectoderm. At 4 hr, cell death was evident in lateral plate mesoderm, somites, and neuroepithelium; the lateral plate mesoderm began to grow dorsally, car

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Author

Jennifer Thompson; John Bannigan

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0040-3709)

Published

2001

Language

EN

Field

Medicine (Health Sciences)