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Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease by Jia Hui Wong; Anna M. Barron; Jafri Malin Abdullah is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease about?

Natural products remain a crucial source of drug discovery for accessible and affordable solutions for healthy aging. __Centella asiatica__ (L.) Urb. (CA) is an important medicinal plant with a wide range of ethnomedicinal uses. Past __in vivo__ and __in vitro__ studies have shown that the plant extract and its key components, such as asiatic acid, asiaticoside, madecassic acid and madecassoside, exhibit a range of anti-inflammatory, neuroprotective, and cognitive benefits mechanistically linked to mitoprotective and antioxidant properties of the plant. Mitochondrial dysfunction and oxidative stress are key drivers of aging and neurodegenerative disease, including Alzheimer’s disease and Parkinson’s disease. Here we appraise the growing body of evidence that the mitoprotective and antioxidative effects of CA may potentially be harnessed for the treatment of brain aging and neurodegenerative disease.

Who reads Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease?

Author

Jia Hui Wong; Anna M. Barron; Jafri Malin Abdullah

Publisher

Frontiers Media SA

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)