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Can I read In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases on EtoBox?
In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases by Arianna Sala; Silvia Paola Caminiti; Luca Presotto; Andrea Pilotto; Claudio Liguori; Agostino Chiaravalloti; Valentina Garibotto; Giovanni Battista Frisoni; Marcello D’Amelio; Barbara Paghera; Orazio Schillaci; Nicola Mercuri; Alessandro Padovani; Daniela Perani is a Medicine article available to read on EtoBox.
What is In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases about?
## Abstract ## Background Preclinical and pathology evidence suggests an involvement of brain dopamine (DA) circuitry in Alzheimer’s disease (AD). We in vivo investigated if, when, and in which target regions [123I]FP-CIT-SPECT regional binding and molecular connectivity are damaged along the AD course. ## Methods We retrospectively selected 16 amyloid-positive subjects with mild cognitive impairment due to AD (AD-MCI), 22 amyloid-positive patients with probable AD dementia (AD-D), and 74 healthy controls, all with available [123I]FP-CIT-SPECT imaging. We tested whether nigrostriatal vs. mesocorticolimbic dopaminergic targets present binding potential loss, via MANCOVA, and alterations in molecular connectivity, via partial correlation analysis. Results were deemed significant at p < 0.05, after Bonferroni correction for multiple comparisons. ## Results We found significant reductions of [123I]FP-CIT binding in both AD-MCI and AD-D compared to controls. Binding reductions were prominent in the major targets of the ventrotegmental-mesocorticolimbic pathway, namely the ventral striatum and the hippocampus, in both clinical groups, and in the cingulate gyrus, in patients with dementia
Who reads In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases?
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- Author
- Arianna Sala; Silvia Paola Caminiti; Luca Presotto; Andrea Pilotto; Claudio Liguori; Agostino Chiaravalloti; Valentina Garibotto; Giovanni Battista Frisoni; Marcello D’Amelio; Barbara Paghera; Orazio Schillaci; Nicola Mercuri; Alessandro Padovani; Daniela Perani
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)