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^212^Pb/^212^Bi‐EDTMP — synthesis and biodistribution of a novel bone seeking alpha‐emitting radiopharmaceutical by Sindre P. Hassfjell; Per Hoff; Øyvind S. Bruland; Jorolf Alstad is a Chemistry article available to read on EtoBox.

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## Abstract At present, haematological toxicity is dose limiting in radionuclide therapy of bone metastases, and there is a need for radiopharmaceuticals with improved tumour/bone marrow dose ratios. Therefore, α‐emitters e.g. ^212^Bi may be more suitable than β‐emitters, because of the short range and high LET values of α‐particles. In this study, ^212^Bi and its mother nuclide ^212^Pb were produced in an isotope generator by collecting gaseous ^220^Rn emanating from barium (^228^Th) stearate. The carrier‐free ^212^Pb/^212^Bi were bound to the chelating bone‐seeking compound ethylene‐diamine‐tetra(methylene‐phosphonic acid) (EDTMP) with 90% yield. The biodistribution in Balb/c mice was investigated by injecting 100 μl of a saline PBS buffer 0.020 M in EDTMP and 10 MBq/ml in ^212^Pb/^212^Bi. Mice were killed in groups of three at 0.5, 2, 13 and 24 h post‐injection times. Both ^212^Pb‐EDTMP and ^212^Bi‐EDTMP localised strongly in the skeleton, especially in the femur, at all time points measured, with the % of injected dose per gram (%ID/g) as high as 15 for ^212^Pb and 13 for ^212^Bi. All other organs investigated showed low uptake of both radionuclides, with the exception of the k

Who reads ^212^Pb/^212^Bi‐EDTMP — synthesis and biodistribution of a novel bone seeking alpha‐emitting radiopharmaceutical?

Author

Sindre P. Hassfjell; Per Hoff; Øyvind S. Bruland; Jorolf Alstad

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

1994

Language

EN

Field

Chemistry (Life Sciences)