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Placental Growth Factor as a Diagnostic Tool for Placental Mediated Fetal Growth Restriction by Shiri Shinar; Melissa Tigert; Swati Agrawal; William A. Parks; John C. kingdom is a Medicine article available to read on EtoBox.

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## Objective: Placental growth factor (plgf) has shown promise in identification of placental fetal growth restriction (fgr). we aimed to investigate the association between plgf and sonographic markers of placental dysfunction and assess its ability to diagnose fgr secondary to maternal vascular malperfusion (mvm). ## Study design: A retrospective study of singleton pregnancies with small for gestational age (sga) fetuses, who had plgf testing at 16-36 weeks. fetuses with major chromosomal and/or structural anomalies and pregnancies with missing outcomes were excluded. sonographic characteristics, perinatal outcomes and placental histopathology were compared between pregnancies with normal and low plgf (<10th percentile for gestational age). the diagnostic accuracy of plgf for prediction of mvm was calculated. ## Results: 130 fetuses met inclusion criteria. compared to normal plgf (n = 65), pregnancies with low plgf (n = 65) were associated with an estimated fetal weight < 5th centile (73.8% (48) vs 53% (35), respectively, p = 0.01), abnormal uterine, umbilical and mca dopplers (p = 0.001 for all), fetal demise (18.8% (12) vs 0% respectively, p = 0.01) and preterm delivery (100% (

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Author

Shiri Shinar; Melissa Tigert; Swati Agrawal; William A. Parks; John C. kingdom

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)