Can I read Advances in Biology and Therapy of Multiple Myeloma : Volume 2: Translational and Clinical Research on EtoBox?

Advances in Biology and Therapy of Multiple Myeloma : Volume 2: Translational and Clinical Research by Nikhil C Munshi; Kenneth C Anderson; SpringerLink (Online service) is a scholarly article available to read on EtoBox.

What is Advances in Biology and Therapy of Multiple Myeloma : Volume 2: Translational and Clinical Research about?

Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatm

Author

Nikhil C Munshi; Kenneth C Anderson; SpringerLink (Online service)

Publisher

Springer New York : Imprint: Springer

Published

2013

Language

EN

ISBN

9781283933971