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The Cost‐effectiveness of Reducing Donor Exposures with Single‐donor Versus Pooled Random‐donor Platelets by I. Lopez‐Plaza; J. Weissfeld; D.J. Triulzi is a Medicine article available to read on EtoBox.

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BACKGROUND: Single‐donor platelets (SDPs) are frequently preferred over pooled random‐donor platelets (RDPs) to reduce donor exposures and the risk for virus transmission or HLA alloimmunization. Transfusion‐associated virus‐transmission risks have significantly decreased, which suggests that white cell reduction by filtration eliminates any difference in the risk of alloimmunization in transfused leukemic patients. Health care reform pressures of make it appropriate to examine the cost‐effectiveness of SDPs versus RDPs in reducing donor exposures. STUDY DESIGN AND METHODS: A decision analysis model was developed and sensitivity analyses were used to assess the incremental cost (dollars/quality‐adjusted life‐year) associated with the use of SDPs versus RDPs for adult patients undergoing hematopoietic progenitor cell transplantation or primary coronary artery bypass grafting (CABG). RESULTS: Among transplant patients, the incremental cost of choosing SDPs as opposed to RDPs ranged from $168,700 to $519,822 per quality‐adjusted life‐year. For patients undergoing primary CABG, the incremental cost was $192,415 (females) and $216,280 (males). Variations in the cost differential between

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Author

I. Lopez‐Plaza; J. Weissfeld; D.J. Triulzi

Publisher

Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)

Published

1999

Language

EN

Field

Medicine (Health Sciences)