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Can I read Resveratrol Inhibits Adipocyte Differentiation and Cellular Senescence of Human Bone Marrow Stromal Stem Cells on EtoBox?
Resveratrol Inhibits Adipocyte Differentiation and Cellular Senescence of Human Bone Marrow Stromal Stem Cells by Dalia Ali; Li Chen; Justyna M. Kowal; Meshail Okla; Muthurangan Manikandan; Moayad AlShehri; Yousef AlMana; Reham AlObaidan; Najd AlOtaibi; Rimi Hamam; Nehad M. Alajez; Abdullah Aldahmash; Moustapha Kassem; Musaad Alfayez is a Medicine article available to read on EtoBox.
What is Resveratrol Inhibits Adipocyte Differentiation and Cellular Senescence of Human Bone Marrow Stromal Stem Cells about?
Bone marrow adipose tissue (BMAT) is a unique adipose depot originating from bone marrow stromal stem cells (BMSCs) and regulates bone homeostasis and energy metabolism. An increased BMAT volume is observed in several conditions e.g. obesity, type 2 diabetes, osteoporosis and is known to be associated with bone fragility and increased risk for fracture. Therapeutic approaches to decrease the accumulation of BMAT are clinically relevant. In a screening experiment of natural compounds, we identified Resveratrol (RSV), a plant-derived antioxidant mediating biological effects via sirtuin- related mechanisms, to exert significant effects of BMAT formation. Thus, we examined in details the effects RSV on adipocytic and osteoblastic differentiation of tolermerized human BMSCs (hBMSC-TERT). RSV (1.0 μM) enhanced osteoblastic differentiation and inhibited adipocytic differentiation of hBMSC-TERT when compared with control and Sirtinol (Sirtuin inhibitor). Global gene expression profiling and western blot analysis revealed activation of a number of signaling pathways including focal adhesion kinase (FAK). Pharmacological inhibition of FAK using (PF-573228) and AKT inhibitor (LY-294002) (5μM)
Who reads Resveratrol Inhibits Adipocyte Differentiation and Cellular Senescence of Human Bone Marrow Stromal Stem Cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dalia Ali; Li Chen; Justyna M. Kowal; Meshail Okla; Muthurangan Manikandan; Moayad AlShehri; Yousef AlMana; Reham AlObaidan; Najd AlOtaibi; Rimi Hamam; Nehad M. Alajez; Abdullah Aldahmash; Moustapha Kassem; Musaad Alfayez
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)