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Emergence of the Uncommon Clone ST944/ST78 Carrying bla~OXA-40-like~ and bla~CTX-M-like~ Genes Among Carbapenem-Nonsusceptible Acinetobacter baumannii in Moscow, Russia by Nikolay Mayanskiy; Igor Chebotar; Natalia Alyabieva; Olga Kryzhanovskaya; Tatiana Savinova; Andrej Turenok; Yulia Bocharova; Anna Lazareva; Svetlana Polikarpova; Olga Karaseva is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Emergence of the Uncommon Clone ST944/ST78 Carrying bla~OXA-40-like~ and bla~CTX-M-like~ Genes Among Carbapenem-Nonsusceptible Acinetobacter baumannii in Moscow, Russia about?

Carbapenem-nonsusceptible (Carba-NS) Acinetobacter baumannii has emerged as an important cause of nosocomial infections. In the present study, we characterized 91 Carba-NS A. baumannii isolates collected from patients of surgical departments and intensive care units at three hospitals in Moscow in 2012-2015. Multilocus sequence typing (MLST) using the Oxford (Oxf) scheme identified 16 sequence types (STs) of three clonal complexes (CCs), including CC92 Oxf (67%), CC109 Oxf (1%), CC944 Oxf (29%), and the singleton ST1100 Oxf (3%). CC944 Oxf was composed of ST944 Oxf (n = 16) and two of its newly described single locus variants ST1103 Oxf (n = 3) and ST1104 Oxf (n = 7); all the three STs were identical to the Pasteur (Pas) MLST scheme ST78. All CC944 Oxf /ST78 Pas isolates were bla OXA-40-like positive and all but one isolate harbored a bla CTX-M-like gene. ST944 Oxf was the only ST found in each of the three study hospitals. Biofilm growth capacity was similar among Carba-NS and nonclonal carbapenem-susceptible isolates. Our data demonstrate the predominance of two clonal lineages among Carba-NS A. baumannii. One of these, the uncommon bla OXA-40-like /bla CTX-M-like -positive clone

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Author

Nikolay Mayanskiy; Igor Chebotar; Natalia Alyabieva; Olga Kryzhanovskaya; Tatiana Savinova; Andrej Turenok; Yulia Bocharova; Anna Lazareva; Svetlana Polikarpova; Olga Karaseva

Publisher

Mary Ann Liebert Inc

Published

2017

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)