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Can I read Physiological and Morphological Characterization of Striatal Neurons Transplanted Into the Striatum of Adult Rats on EtoBox?
Physiological and Morphological Characterization of Striatal Neurons Transplanted Into the Striatum of Adult Rats by John P. Walsh; Feng C. Zhou; Chester D. Hull; Robin S. Fisher; Michael S. Levine; Nathaniel A. Buchwald is a Neuroscience article available to read on EtoBox.
What is Physiological and Morphological Characterization of Striatal Neurons Transplanted Into the Striatum of Adult Rats about?
Physiological and morphological properties of transplanted striatal neurons (TSNs) were examined in a n in vitro slice preparation. Fetal striatal tissue (E13-14) was implanted as a dissociated cellular suspension into the striatum of adult rats. Intracellular records were obtained from TSNs 2-6 weeks after transplantation. TSNs exhibited biophysical, morphological, and synaptic properties characteristic of normal striatal neurons, despite the disruption involved in processing of the fetal tissue. Differences were observed, however, between the TSNs and host striatal neurons. TSNs consistently had higher input resistance values than host striatal neurons as determined by neuronal responses to intracellular current injection. Stimulation of adjacent host striatum elicited both excitatory and inhibitory postsynaptic potentials in TSNs. By contrast, the same stimuli elicited only excitatory responses in host striatal neurons. Morphologically, TSNs resembled host medium-size spiny neurons as demonstrated by intracellular injection of lucifer yellow. However, the complexity of dendritic branching and the density of spines on the dendrites were less than that observed for host striatal n
Who reads Physiological and Morphological Characterization of Striatal Neurons Transplanted Into the Striatum of Adult Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- John P. Walsh; Feng C. Zhou; Chester D. Hull; Robin S. Fisher; Michael S. Levine; Nathaniel A. Buchwald
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 1987
- Language
- EN
- Field
- Neuroscience (Life Sciences)