Opening book details…
Can I read High-resolution three-dimensional MR angiography of rodent tumors: Morphologic characterization of intratumoral vasculature on EtoBox?
High-resolution three-dimensional MR angiography of rodent tumors: Morphologic characterization of intratumoral vasculature by Christian Fink; Fabian Kiessling; Michael Bock; Matthias Philipp Lichy; Bernd Misselwitz; Peter Peschke; Norbert E. Fusenig; Rainer Grobholz; Stefan Delorme is a Medicine article available to read on EtoBox.
What is High-resolution three-dimensional MR angiography of rodent tumors: Morphologic characterization of intratumoral vasculature about?
## Abstract ## Purpose To evaluate high‐resolution three‐dimensional MR angiography (MRA) for the visualization and morphologic characterization of intratumoral vasculature. ## Materials and Methods Two subcutaneous rodent tumor models (human skin carcinoma HaCaT‐ras‐A‐5RT3 grown in nude mice and rat prostate carcinoma R3327‐AT1 grown in Copenhagen rats) were examined with a clinical 1.5 T MR‐system. For MRA a dedicated high‐resolution three‐dimensional gradient echo pulse sequence with a voxel size of 166 × 206 × 320 μm^3^ was performed after injection of Gadomer‐17. The image analysis included a correlation of intratumoral vessels with histology. Signal intensity measurements were performed in the vena cava, the tumor underlying muscle, and in various regions of the tumor. Signal‐to‐noise‐ratios (SNR) and contrast‐to‐noise‐ratios (CNR) were calculated from this measurement. ## Results High‐resolution MRA allowed a clear distinction of intratumoral blood vessels. The mouse tumor model tended to be strongly vascularized with several intratumoral blood vessels clearly displayed by MRA. When correlated with histology, these intratumoral blood vessels had a size in the range of 300 to
Who reads High-resolution three-dimensional MR angiography of rodent tumors: Morphologic characterization of intratumoral vasculature?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Christian Fink; Fabian Kiessling; Michael Bock; Matthias Philipp Lichy; Bernd Misselwitz; Peter Peschke; Norbert E. Fusenig; Rainer Grobholz; Stefan Delorme
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)