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The Role of Sex Hormones in Multiple Sclerosis by Mirla Avila; Arpana Bansal; John Culberson; Alan N. Peiris is a Medicine article available to read on EtoBox.

What is The Role of Sex Hormones in Multiple Sclerosis about?

Multiple sclerosis (MS) is a chronic inflammatory demyelination disorder with an immune-mediated pathophysiology that affects the central nervous system (CNS). Like other autoimmune conditions, it has a predilection for female gender. This suggests a gender bias and a possible hormonal association. Inflammation and demyelination are hallmarks of MS. Oligodendrocytes are the myelinating cells of the CNS and these continue to be generated by oligodendrocyte precursor cells (OPCs). The process of remyelination represents a major form of plasticity in the developing adult CNS. Remyelination does occur in MS, but the process is largely inadequate and/or incomplete. Current treatment strategies primarily focus on reducing inflammation or immunosuppression, but there is a need for more extensive research on re-myelination as a possible mechanism of treatment. Previous studies have shown that pregnancy leads to an increase in OPC proliferation, oligodendrocyte generation and the number of myelinated axons in the maternal CNS. Studies have also suggested that this remyelination is possibly mediated by estriol. Sex hormones in particular have been shown to have an immuno-protective effect in

Who reads The Role of Sex Hormones in Multiple Sclerosis?

Author

Mirla Avila; Arpana Bansal; John Culberson; Alan N. Peiris

Publisher

S. Karger AG

Published

2018

Language

EN

Field

Medicine (Health Sciences)