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Improvement in breast lesion characterization with dynamic contrast‐enhanced MRI using pharmacokinetic modeling and bookend T ~1~ measurements by Greg O. Cron; Frederick Kelcz; Giles E. Santyr is a Medicine article available to read on EtoBox.

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## Abstract Dynamic contrast‐enhanced breast MR imaging was performed on 14 patients (five cancerous lesions, nine benign) with slice‐selective spoiled gradient‐recalled echo (2D SPGR) imaging. Adiabatic saturation recovery __T__~1~ measurements were performed before (__T__~1pre~) and after (__T__~1post~) 2D SPGR imaging. These two “bookend” __T__~1~ measurements were used to calibrate the equations which were employed to convert the time course of the 2D SPGR signal strength to __T__~1~‐vs.‐time, which in turn was used to compute the gadolinium concentration‐vs.‐time ([C](t)) in the lesion. The extraction‐flow product (EF) was computed for each lesion by pharmacokinetic modeling of [C](t). For this study, EF provided a sensitivity and specificity for cancer of 100% and 78%, respectively. When only __T__~1pre~ was used to estimate [C](t) (which assumes a priori knowledge of the shape and amplitude of the slice profile), the sensitivity and specificity fell to 80% and 56%, respectively. This is presumably due to unexpected variations in the shape and/or amplitude of the slice profile, which could be caused by factors such as patient‐to‐patient variations in breast geometry or incons

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Author

Greg O. Cron; Frederick Kelcz; Giles E. Santyr

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2004

Language

EN

Field

Medicine (Health Sciences)