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A Single Administration of Ascorbic Acid Rapidly Reverses Depressive-like Behavior and Hippocampal Synaptic Dysfunction Induced by Corticosterone in Mice by Daiane B. Fraga; Anderson Camargo; Gislaine Olescowicz; Dayane Azevedo Padilha; Francielle Mina; Josiane Budni; Patricia S. Brocardo; Ana Lúcia S. Rodrigues is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A Single Administration of Ascorbic Acid Rapidly Reverses Depressive-like Behavior and Hippocampal Synaptic Dysfunction Induced by Corticosterone in Mice about?
Ketamine is the prototype for glutamate-based fast-acting antidepressants. The establishment of ketamine-like drugs is still a challenge and ascorbic acid has emerged as a candidate. This study investigated the ascorbic acid's ability to induce a fast antidepressant-like response and to improve hippocampal synaptic markers in mice subjected to chronic corticosterone (CORT) administration. CORT was administered for 21 days, followed by a single administration of ascorbic acid (1 mg ∕Kg, p.o.), ketamine (1 mg ∕Kg, i.p.) or fluoxetine (10 mg ∕Kg, p.o.) in mice. Depressive-like behavior, hippocampal synaptic proteins immunocontent, dendrite spines density in the dentate gyrus (DG) were analyzed 24 h following treatments. The administration of ascorbic acid or ketamine, but not fluoxetine, counteracted CORT-induced depressive-like behavior in the tail suspension test (TST). CORT administration reduced PSD-95, GluA1, and synapsin (synaptic markers) immunocontent, and these alterations were reversed by ascorbic acid or ketamine, but only ketamine reversed the CORT-induced reduction on GluA1 immunocontent. In the ventral and dorsal DG, CORT decreased filopodia-, thin-and stubby-shaped spin
Who reads A Single Administration of Ascorbic Acid Rapidly Reverses Depressive-like Behavior and Hippocampal Synaptic Dysfunction Induced by Corticosterone in Mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Daiane B. Fraga; Anderson Camargo; Gislaine Olescowicz; Dayane Azevedo Padilha; Francielle Mina; Josiane Budni; Patricia S. Brocardo; Ana Lúcia S. Rodrigues
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)