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Oxidative DNA damage and cytogenetic effects in flight engineers exposed to cosmic radiation by I.H. Zwingmann; I.J. Welle; M. van Herwijnen; J.J.M. Engelen; P.A.E.L. Schilderman; Tj. Smid; J.C.S. Kleinjans is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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This study set out to analyze biomarkers for genotoxic events, e.g., oxidative DNA damage, chromosomal damage and hprt mutations, among flight personnel, who are known to be occupationally exposed to ionizing radiation of cosmic origin. Twenty-three flight engineers were recruited while ground personnel served as a matched control group. Cumulative radiation doses during flight were calculated on the basis of subjects' flight records assuming an exposure rate of 6 microSv per hour of flight. Oxidative DNA damage in peripheral lymphocytes from flight engineers appeared significantly increased in comparison with controls and was associated with cumulative exposure to cosmic radiation. Frequencies of peripheral lymphocyte chromosome aberrations, micronuclei and hprt mutations appeared also to be increased in flight engineers, but not significantly. It was also observed that DNA damage was higher in flight engineers with a relatively shorter flight history in comparison with flight engineers with higher cumulative exposures to radiation, suggesting adaptation to DNA damage caused by ionizing radiation. DNA repair activities measured as unscheduled DNA synthesis were clearly increased i

Who reads Oxidative DNA damage and cytogenetic effects in flight engineers exposed to cosmic radiation?

Author

I.H. Zwingmann; I.J. Welle; M. van Herwijnen; J.J.M. Engelen; P.A.E.L. Schilderman; Tj. Smid; J.C.S. Kleinjans

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0893-6692)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)