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Can I read Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity on EtoBox?
Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity by Linlin Sheng; Qi Luo; Ligong Chen is a Medicine article available to read on EtoBox.
What is Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity about?
The past decade exposed the importance of many homeostasis and metabolism related proteins in autoimmunity disease and inflammation. Solute carriers (SLCs) are a group of membrane channels that can transport amino acids, the building blocks of proteins, nutrients, and neurotransmitters. This review summarizes the role of SLCs amino acid transporters in inflammation and autoimmunity disease. In detail, the importance of Glutamate transporters SLC1A1, SLC1A2, and SLC1A3, mainly expressed in the brain where they help prevent glutamate excitotoxicity, is discussed in the context of central nervous system disorders such as multiple sclerosis. Similarly, the cationic amino acid transporter SLC7A1 (CAT1), which is an important arginine transporter for T cells, and SLC7A2 (CAT2), essential for innate immunity. SLC3 family proteins, which bind with light chains from the SLC7 family (SLC7A5, SLC7A7 and SLC7A11) to form heteromeric amino acid transporters, are also explored to describe their roles in T cells, NK cells, macrophages and tumor immunotherapies. Altogether, the link between SLC amino acid transporters with inflammation and autoimmunity may contribute to a better understanding of u
Who reads Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Linlin Sheng; Qi Luo; Ligong Chen
- Publisher
- American Society for Pharmacology & Experimental Therapeutics (ASPET)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Life Sciences)