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Betulinic Acid Inhibits High Glucose‐induced Vascular Smooth Muscle Cells Proliferation and Migration by Jung Joo Yoon; Yun Jung Lee; Jin Sook Kim; Dae Gill Kang; Ho Sub Lee is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract The proliferation of vascular smooth muscle cells may perform a crucial role in the pathogenesis of diabetic vascular disease. The principal objective of this study was to determine the effects of betulinic acid (BA) on human aortic smooth muscle cell (HASMC) proliferation induced by high glucose (HG). In this study, [^3^H]‐thymidine incorporation under 25 mM HG was accelerated significantly as compared with 5.5 mM glucose, and this increase was inhibited significantly by BA treatment. We utilized Western blotting analysis to evaluate the effects of BA on cell‐cycle regulatory proteins. HG induced the expression of cyclins/CDKs and reduced the expression of p21^waf1/cip1^/p27^kip1^. However, BA also attenuated the expression of HG‐induced cell‐cycle regulatory proteins. The results of gelatin zymography demonstrated that the HG‐treated HASMC secreted gelatinases, probably including MMP‐2/‐9, which may be involved in the invasion and migration of HASMC. Additionally, BA suppressed the protein and mRNA expression levels of MMP‐2/‐9 in a dose‐dependent manner. BA inhibited the production of HG‐induced hydrogen peroxide (H~2~O~2~) and the formation of DCF‐sensitive intracel
Who reads Betulinic Acid Inhibits High Glucose‐induced Vascular Smooth Muscle Cells Proliferation and Migration?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jung Joo Yoon; Yun Jung Lee; Jin Sook Kim; Dae Gill Kang; Ho Sub Lee
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)