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Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis by Chaitra Venugopal; Christopher Shamir; Sivapriya Senthilkumar; Janitri Venkatachala Babu; Peedikayil Kurien Sonu; Kusum Jain Nishtha; Kiranmai S Rai; K Shobha; Anandh Dhanushkodi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis about?
## Background: Neurodegenerative diseases comprise a group of disorders for which no treatment is available till date. stem cell based therapy offers great hope and promise. however, stem cell transplantation is associated with certain disadvantages like poor targeted migration, engraftment and survival of the transplanted cells. ## Material & method: Exosomes, a type of extracellular membrane vesicle released by all cell types including stem cells, offer an alternative to stem cell transplantation. exosome carry a wide array of biomolecules and are implicated in exhibiting substantial benefits in the repair/regeneration of the injured tissue. thus, exosomes offer an alternative therapeutic approach as a substitute of cell transplantation. in order to utilize exosomes for therapeutic purpose, it is essential to evaluate the appropriate passage number and the dosage to avoid possible cytotoxic effects. here, we isolated exosomes from different passages of rat bone marrow mesenchymal stem cells (bm-msc) and analysed the neuroprotective potential of bm-msc exosomes in an in vitro model of excitotoxicity. ## Result: Our results demonstrated that the exosomes isolated from early passage
Who reads Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Chaitra Venugopal; Christopher Shamir; Sivapriya Senthilkumar; Janitri Venkatachala Babu; Peedikayil Kurien Sonu; Kusum Jain Nishtha; Kiranmai S Rai; K Shobha; Anandh Dhanushkodi
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)