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Combination of Human Plasminogen Kringle 5 with Ionizing Radiation Significantly Enhances the Efficacy of Antitumor Effect by Guang-Hui Jin; Ding-Yuan Ma; Ning Wu; Faiz M.M.T Marikar; Shun-Zi Jin; Wei-Wei Jiang; Yan Liu; Zi-Chun Hua is a Medicine article available to read on EtoBox.
What is Combination of Human Plasminogen Kringle 5 with Ionizing Radiation Significantly Enhances the Efficacy of Antitumor Effect about?
## Abstract Antiangiogenic therapy could destroy tumor vasculature and inhibit tumor growth. It might inhibit tumor growth significantly when used as a single treatment modality and its therapeutic benefit may even be greater when used in combination with established treatment modalities such as radiation therapy (RT). In the present report, we investigated the effect of recombinant human plasminogen kringle 5 domain (rhK5) in combination with ionizing radiation on angiogenesis, tumor growth and survival in a murine Lewis lung carcinoma (LLC) tumor model. Combined treatment using rhK5 and radiotherapy displayed obvious suppressive effect on LLC tumor growth as compared with single treatment with either modality (__p__ < 0.05), and resulted in a more additive effect on tumor growth delay in this model. In addition, combined treatment significantly enhanced the survival of mice and no toxic effect, such as weight loss, was observed. The significant antitumor effect of rhK5 plus radiation was associated with a direct suppression effect on early neoangiogenesis and tumor cell apoptosis. Furthermore, the expression of VEGF and HIF‐1α in tumor tissue correlated well with decreased vessel
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It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Guang-Hui Jin; Ding-Yuan Ma; Ning Wu; Faiz M.M.T Marikar; Shun-Zi Jin; Wei-Wei Jiang; Yan Liu; Zi-Chun Hua
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)