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Scorpion α‐Like Toxins, Toxic to Both Mammals and Insects, Differentially Interact with Receptor Site 3 on Voltage‐gated Sodium Channels in Mammals and Insects by Sandrine Cestèle; Maria Stankiewicz; Pascal Mansuelle; Michel De Waard; Bénédicte Dargent; Nicolas Gilles; Marcel Pelhate; Hervé Rochat; Marie‐France Martin‐Eauclaire; Dalia Gordon is a Neuroscience article available to read on EtoBox.
What is Scorpion α‐Like Toxins, Toxic to Both Mammals and Insects, Differentially Interact with Receptor Site 3 on Voltage‐gated Sodium Channels in Mammals and Insects about?
## Abstract α‐Like toxins, a unique group designated among the scorpion α‐toxin class that inhibit sodium channel inactivation, are highly toxic to mice but do not compete for α‐toxin binding to receptor site 3 on rat brain sodium channels. We analysed the sequence of a new α‐like toxin, which was also highly active on insects, and studied its action and binding on both mammalian and insect sodium channels. Action of the α‐like toxin on isolated cockroach axon is similar to that of an α‐toxin, and the radioactive toxin binds with a high affinity to insect sodium channels. Other sodium channel neurotoxins interact competitively or allosterically with the insect α‐like toxin receptor site, similarly to α‐toxins, suggesting that the α‐like toxin receptor site is closely related to receptor site 3. Conversely, on rat brain sodium channels, specific binding of ^125^I‐α‐like toxin could not be detected, although at high concentration it inhibits sodium current inactivation on rat brain sodium channels. The difficulty in measuring binding to rat brain channels may be attributed to low‐affinity binding due to the acidic properties of the α‐like toxins that also impair the interaction with
Who reads Scorpion α‐Like Toxins, Toxic to Both Mammals and Insects, Differentially Interact with Receptor Site 3 on Voltage‐gated Sodium Channels in Mammals and Insects?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Sandrine Cestèle; Maria Stankiewicz; Pascal Mansuelle; Michel De Waard; Bénédicte Dargent; Nicolas Gilles; Marcel Pelhate; Hervé Rochat; Marie‐France Martin‐Eauclaire; Dalia Gordon
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 1999
- Language
- EN
- Field
- Neuroscience (Life Sciences)