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Monocarboxylate transporters (MCTs) are crucial for tumor metabolism, facilitating the uptake and export of metabolites like lactate and pyruvate, which are vital for maintaining the glycolytic state of tumor cells. High expression of MCT1 and MCT4 is linked to tumor malignancy and poor prognosis, making them potential therapeutic targets. Current MCT inhibitors show promise but lack selectivity, indicating a need for the development of more targeted therapies in conjunction with traditional treatments.

Author

huoxue19921125

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EN