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Estetrol (E4) is a novel natural estrogen with unique pharmacological properties, primarily stimulating nuclear estrogen receptor alpha (ERα) while avoiding activation of membrane ERα, leading to tissue-specific effects. It is currently available as a combined oral contraceptive with drospirenone and is undergoing clinical development for hormone replacement therapy (HRT), showing a lower impact on hemostatic and metabolic parameters compared to other estrogens. E4 also demonstrates potential therapeutic ap

Author

marialecifuentes

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EN