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Studies on the Development of Oral Colon Targeted Drug Delivery Systems for Metronidazole in the Treatment of Amoebiasis by Y.S.R. Krishnaiah; P.R. Bhaskar Reddy; V. Satyanarayana; R.S. Karthikeyan is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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The aim of the present study is to develop colon targeted drug delivery sytems for metronidazole using guar gum as a carrier. Matrix, multilayer and compression coated tablets of metronidazole containing various proportions of guar gum were prepared. All the formulations were evaluated for the hardness, drug content uniformity, and were subjected to in vitro drug release studies. The amount of metronidazole released from tablets at different time intervals was estimated by high performance liquid chromatography method. Matrix tablets and multilayer tablets of metronidazole released 43-52% and 25-44% of the metronidazole, respectively, in the physiological environment of stomach and small intestine depending on the proportion of guar gum used in the formulation. Both the formulations failed to control the drug release within 5 h of the disolution study in the physiological environment of stomach and small intestine. The compression coated formulations released less than 1% of metronidazole in the physiological environment of stomach and small intestine. When the dissolution study was continued in simulated colonic fluids, the compression coated tablet with 275 mg of guar gum coat re

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Author

Y.S.R. Krishnaiah; P.R. Bhaskar Reddy; V. Satyanarayana; R.S. Karthikeyan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2002

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)