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Comparison of 18F-FDG-PET and standard procedures for the pretreatment staging of children and adolescents with Hodgkin’s disease by Edita Kabickova; David Sumerauer; Eliska Cumlivska; Eva Drahokoupilova; Michaela Nekolna; Marketa Chanova; Marie Hladikova; Roman Kodet; Otakar Belohlavek is a Medicine article available to read on EtoBox.

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## Purpose: The aim of this study was to perform a prospective, blinded comparison of( 18)f-fluorodeoxyglucose positron emission tomography (fdg-pet) and conventional staging methods (csms) for initial staging of children and adolescents with hodgkin's disease (hd). ## Methods: Over a period of 4 years, 55 children and adolescents with hd (mean age 15.5 years, range 3.9-18.9 years) were prospectively recruited into the study. they underwent 61 fdg-pet studies using a dedicated whole-body pet scanner as a part of their initial staging work-up. pet findings were correlated with the results of csms, including computed tomography (ct), ultrasound, bone scanning and bone marrow examination. discordant findings were resolved by magnetic resonance imaging or clinical follow-up (range 2-47 months). ## Results: Pet correctly changed the staging in 15% of patients (seven upstagings, two downstagings). only two out of 61 patients (3%) were not accurately staged by pet; in these children, pet missed small lymphoma nodules detected on lung ct. the sensitivity of pet and csms for pretreatment staging was 96.5% and 87.5%, respectively; specificity was 100% and 60%, and accuracy, 96.7% and 85.2%,

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Author

Edita Kabickova; David Sumerauer; Eliska Cumlivska; Eva Drahokoupilova; Michaela Nekolna; Marketa Chanova; Marie Hladikova; Roman Kodet; Otakar Belohlavek

Publisher

Springer Science and Business Media LLC

Published

2006

Language

EN

Field

Medicine (Health Sciences)