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Meta-analysis Comparing Catheter Guided Ablation Versus Conventional Medical Therapy for Patients with Atrial Fibrillation and Heart Failure with Reduced Ejection Fraction by Akram Y. Elgendy; Ahmed N. Mahmoud; Muhammad S. Khan; Maryam R. Sheikh; Mohammad K. Mojadidi; Mohamed Omer; Islam Y. Elgendy; Anthony A. Bavry; Kenneth A. Ellenbogen; William M. Miles; Matthew McKillop is a Medicine article available to read on EtoBox.

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The prognostic benefit of catheter ablation (CA) for atrial fibrillation in the setting of heart failure (HF) with reduced ejection fraction (EF) is unclear. A systematic search of medical literature was limited to randomized controlled trials. The primary outcome was all-cause mortality, and secondary outcomes were HF hospitalizations, stroke, left ventricular EF improvement, change in 6-minute walk test, and change in Minnesota living with HF questionnaire (Δ MLHFQ). Random effects risk ratios (RR) were calculated for categorical outcomes and standardized mean differences (SMD) for continuous ones, using Der-Simonian and Liard model. A total of 775 ambulatory patients from 6 trials were included. The mean EF was 31% with a mean New York Heart Association classification class 2.5. At a mean follow-up of 26 months, CA was associated with lower incidences of all-cause mortality (RR 0.50, 95% confidence intervals [CI] 0.34 to 0.74, I = 0%, p <0.0001), and HF hospitalizations (RR 0.58, 95% CI 0.41 to 0.81, p = 0.002, I = 0%), with similar incidences of stroke. Left ventricular EF improvement (SMD = 2.58, 95% CI 0.88 to 4.27), and change in Minnesota living with heart failure HF questi

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Author

Akram Y. Elgendy; Ahmed N. Mahmoud; Muhammad S. Khan; Maryam R. Sheikh; Mohammad K. Mojadidi; Mohamed Omer; Islam Y. Elgendy; Anthony A. Bavry; Kenneth A. Ellenbogen; William M. Miles; Matthew McKillop

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0002-9149)

Published

2018

Language

EN

Field

Medicine (Health Sciences)