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The Potential of Raman Spectroscopy in the Diagnosis of Dysplastic and Malignant Oral Lesions by Ibrahim, Ola (author);Toner, Mary (author);Flint, Stephen (author);Byrne, Hugh J. (author);Lyng, Fiona M. (author) is a Medicine article available to read on EtoBox.

What is The Potential of Raman Spectroscopy in the Diagnosis of Dysplastic and Malignant Oral Lesions about?

Early diagnosis, treatment and/or surveillance of oral premalignant lesions are important in preventing progression to oral squamous cell carcinoma (OSCC). The current gold standard is through histopathological diagnosis, which is limited by inter- and intra-observer errors and sampling errors. The objective of this work was to use Raman spectroscopy to discriminate between benign, mild, moderate and severe dysplasia and OSCC in formalin fixed paraffin preserved (FFPP) tissues. The study included 72 different pathologies from which 17 were benign lesions, 20 mildly dysplastic, 20 moderately dysplastic, 10 severely dysplastic and 5 invasive OSCC. The glass substrate and paraffin wax background were digitally removed and PLSDA with LOPO cross-validation was used to differentiate the pathologies. OSCC could be differentiated from the other pathologies with an accuracy of 70%, while the accuracy of the classifier for benign, moderate and severe dysplasia was ~60%. The accuracy of the classifier was lowest for mild dysplasia (~46%). The main discriminating features were increased nucleic acid contributions and decreased protein and lipid contributions in the epithelium and decreased col

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Author

Ibrahim, Ola (author);Toner, Mary (author);Flint, Stephen (author);Byrne, Hugh J. (author);Lyng, Fiona M. (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)