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Rheumatoid arthritis is a chronic autoimmune disorder causing symmetrical polyarthritis affecting 0.5-1% of the population worldwide, peaking between ages 30-50. It is characterized by synovitis and infiltration of inflammatory cells into synovium, generating new blood vessels and adhesion molecules that allow extravasation of leukocytes. This proliferating synovium, called pannus, destroys articular cartilage and bone, producing erosions. Diagnosis is based on morning stiffness >1 hour, arthritis of 3+ joi

Author

Sani muzakir

Language

EN