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Clonality of B-cells in portal lymphoid infiltrates of HCV-infected livers by Magalini, Alba Rosa; Facchetti, Fabio; Salvi, Lucia; Fontana, Lucia; Puoti, Massimo; Scarpa, Aldo is a Medicine article available to read on EtoBox.

What is Clonality of B-cells in portal lymphoid infiltrates of HCV-infected livers about?

Evidence has been accumulating in favour of a role for hepatitis C virus (HCV) in the pathogenesis of human lymphoproliferative disorders. HCV infection has been documented in the majority of patients with essential mixed cryoglobulinaemia type II (MC-II); in patients with HCV infection, B-cell clonal expansions have been detected in peripheral blood and bone marrow, and a high prevalence of B-cell non-Hodgkin's lymphomas has been documented. Liver biopsies in chronic hepatitis C frequently show portal lymphoid infiltrates with features of B follicles, whose clonality has not yet been investigated. This study has analysed the B-cell clonality of portal lymphoid infiltrates from 16 patients with chronic HCV hepatitis. Portal tracts showing obvious lymphoid infiltrates were microdissected from the paraffin-embedded liver tissue sections and the clonality of lymphoid B-cells was tested using a polymerase chain reaction (PCR) approach designed to identify immunoglobulin heavy chain gene (IgH) rearrangements. A successful IgH-PCR analysis was achieved in 35 lymphoid infiltrates from 11 patients (seven with and four without MC-II) and yielded a single band in 21 cases, two bands in ten c

Who reads Clonality of B-cells in portal lymphoid infiltrates of HCV-infected livers?

Author

Magalini, Alba Rosa; Facchetti, Fabio; Salvi, Lucia; Fontana, Lucia; Puoti, Massimo; Scarpa, Aldo

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1998

Language

EN

Field

Medicine (Health Sciences)