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MKL1 Promotes Endothelial To-Mesenchymaltransitionand Liver Fibrosis by activatingTWIST1 Transcription by h576218540 is a document available to read on EtoBox.
The study investigates the role of MKL1 in promoting endothelial-to-mesenchymal transition (EndMT) and liver fibrosis, revealing that MKL1 activates TWIST1 transcription via STAT3. Inhibition or deletion of MKL1 in endothelial cells significantly reduces liver fibrosis in mouse models by suppressing EndMT. These findings suggest that targeting the STAT3-MKL1-TWIST1 axis could provide new therapeutic strategies for liver fibrosis.
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- h576218540
- Language
- EN