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A Biosynthetic Classification of Fungal and Streptomycete Fused-Ring Aromatic Polyketides by Robert Thomas is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Dedicated to the late Professor Harold Raistrick (F.R.S.) in recognition of his seminal contributions to the chemistry of fungi Polyketides are one of the largest and most structurally diverse classes of naturally occurring compounds, ranging from simple aromatic metabolites to complex macrocyclic lactones. Fungi and filamentous bacteria, particularly the actinomycetes, are major sources of polycyclic aromatic structures, which include many clinically important antibiotics and other useful metabolites. These fused-ring polyketides are formed by the action of polyketide synthases (PKSs), which catalyse the assembly, folding and crosslinking of poly-b-ketoacyl intermediates. In view of the taxonomic gulf between the eukaryotic fungi and prokaryotic bacteria, it is not surprising that they are rarely found to produce structurally identical fused-ring metabolites. A review of [ 13 C 2 ]acetate incorporation data has revealed consistent differences in the reported cyclisation patterns, which require regiospecifically distinct crosslinking of otherwise identical linear polyketide precursors. This observation provides the basis for a structural and biosynthetic classification of microbial

Who reads A Biosynthetic Classification of Fungal and Streptomycete Fused-Ring Aromatic Polyketides?

Author

Robert Thomas

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1439-4227)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)