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Synthesis, Spectroscopic Elucidation and Biomedical Applications of 1,10-Phenanthroline Derivatives of Lead (II) by Ashu Chaudhary; R.V. Singh is a Chemistry article available to read on EtoBox.

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A huge world of inorganic drugs is waiting to be discovered. The inorganic drugs can be metal complexes wherein at least some of the ligands remain bound to the metal even on reaching the target site or where the ligands simply act as a vehicle for delivery and are not critical for activity. In some cases the ligands themselves may be the active species. A few inorganic compounds are already successful drugs. However, some more still needs to be done. The complexes can be formed in the body to handle dysfunction due to metal poisoning. Metal has the power to induce biological activity by interaction with DNA by thread binding mechanism. Achieving optimal chemopreventive potency with lowest toxicity continues to be our primary goal in designing and developing lead(II) complexes of phenenthrolines and dicarboxylic acids. These complexes have been characterized by chemical analysis, IR, 'H NMR, n C NMR and 20 Pb NMR spectral studies, X-ray powder diffraction, molecular weight determinations and conductivity measurements. An octahedral geometry around the lead atom is suggested for [Pb(MacL n )Cl 2 ] complexes. The pathogenicity of certain microbial infections associated with the compl

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Author

Ashu Chaudhary; R.V. Singh

Publisher

Walter de Gruyter GmbH

Published

2005

Language

EN

Field

Chemistry (Physical Sciences)