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Humoral and cellular immune memory response 12 years following single dose vaccination against hepatitis A in Argentinian children by A. Urueña; M.N. Badano; P. Baré; J. González; R. Vicentín; R. Calli; M.C. Cañero-Velasco; S. Fink; C. Vizzotti is a Medicine article available to read on EtoBox.
What is Humoral and cellular immune memory response 12 years following single dose vaccination against hepatitis A in Argentinian children about?
Infants' universal hepatitis A virus (HAV) single-dose vaccination has been highly effective for controlling HAV infection in Argentina, and in other Latin-American countries that adopted that strategy. Although antibodies wane over time, this has not been associated with HAV outbreaks or breakthrough infections, suggesting a relevant role for memory immunity. This study assessed long term humoral and cellular immune memory response after an average of 12 years follow-up of HAV single-dose vaccination. We selected 81 HAV-single dose vaccinated individuals from a 2015 study, including 54 with unprotective (UAL) and 27 with protective antibody levels (PAL) against HAV. Humoral memory response was assessed by measuring anti-HAV antibody titers at admission in both groups, and 30 days after a booster dose in the UAL group. Flow cytometry analysis of peripheral blood mononuclear cell samples stimulated with HAV antigen was performed in 47/81 individuals (21 with PAL, 26 with UAL) to identify activated CD4 + memory T cells or CD8 + memory T cells. The results showed that 48/52 (92%) individuals from UAL group who completed follow up reached protective levels after booster dose. In the PA
Who reads Humoral and cellular immune memory response 12 years following single dose vaccination against hepatitis A in Argentinian children?
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- Author
- A. Urueña; M.N. Badano; P. Baré; J. González; R. Vicentín; R. Calli; M.C. Cañero-Velasco; S. Fink; C. Vizzotti
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)