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Biological Responses of Human Osteoblasts and Osteoclasts to Flame-sprayed Coatings of Hydroxyapatite and Fluorapatite Blends by K.A. Bhadang; C.A. Holding; H. Thissen; K.M. McLean; J.S. Forsythe; D.R. Haynes is a Engineering article available to read on EtoBox.

What is Biological Responses of Human Osteoblasts and Osteoclasts to Flame-sprayed Coatings of Hydroxyapatite and Fluorapatite Blends about?

The aim of this study was to determine how the activities of human osteoblastic cells and osteoclasts respond to substrates of thermal-sprayed mechanical blends of hydroxyapatite and fluorapatite with a view of determining an optimal blend ratio for osseointegration. Human osteoblastic cells and osteoclasts were grown on titanium alloy discs coated with blends of hydroxyapatite and fluorapatite, with concentrations ranging from 0 to 100% fluorapatite. Human osteoblastic cells attached in greater numbers and proliferated at a greater rate on blends containing 40% fluorapatite. Human osteoblastic cells grown on blends containing 40% fluorapatite for 7 days also expressed the highest levels of mRNA for several proteins involved with regulating bone metabolism (osteoprotegerin and receptor activator nuclear factor kappa B ligand), and bone formation (osteopontin, osteonectin and bone sialoprotein 1). Osteoclasts resorbed the dentine but poorly resorbed the hydroxyapatite-fluorapatite blends, particularly at high levels of fluorapatite. This in vitro study demonstrates that thermal-sprayed hydroxyapatitecoatings containing 40% fluorapatite may promote optimal bone growth and improve oss

Who reads Biological Responses of Human Osteoblasts and Osteoclasts to Flame-sprayed Coatings of Hydroxyapatite and Fluorapatite Blends?

Author

K.A. Bhadang; C.A. Holding; H. Thissen; K.M. McLean; J.S. Forsythe; D.R. Haynes

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1742-7061)

Published

2010

Language

EN

Field

Engineering (Physical Sciences)