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Population Pharmacokinetics of Gentamicin in Patients with Cancer by M. C. Rosario; A. H. Thomson; D. I. Jodrell*; C. A. Sharp; H. L. Elliott is a Medicine article available to read on EtoBox.

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## Aims: The purpose of this study was to describe the population pharmacokinetics of gentamicin in patients with cancer, to identify possible relationships between clinical covariates and population pharmacokinetic parameter estimates and to examine the relevance of existing dosage nomograms in light of the population model developed in these patients. ## Methods: Data were collected prospectively from 210 patients with cancer and were analysed with package nonmem. data were split into two sets: a population data set and an evaluation set. creatinine clearance was estimated using measured creatinine concentrations and using 'low' creatinines set to a minimum of 60 micromol l(-1), 70 micromol l(-1) or 88.4 micromol l(-1) ## Results: A two compartment model was fitted to the concentration-time curve. two best models were obtained, one that related clearance to estimated creatinine clearance (minimum creatinine value 60 micromol l(-1)) and the other that related clearance to age, creatinine concentration and body surface area. volume of the central compartment was influenced by body surface area and albumin concentration. for both models 90% of measured concentrations lay within the

Who reads Population Pharmacokinetics of Gentamicin in Patients with Cancer?

Author

M. C. Rosario; A. H. Thomson; D. I. Jodrell*; C. A. Sharp; H. L. Elliott

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

1998

Language

EN

Field

Medicine (Health Sciences)