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Optimizing brain tissue contrast with EPI: A simulated annealing approach by Vasiliki N. Ikonomidou; Peter van Gelderen; Jacco A. de Zwart; Masaki Fukunaga; Jeff H. Duyn is a Medicine article available to read on EtoBox.

What is Optimizing brain tissue contrast with EPI: A simulated annealing approach about?

## Abstract A new magnetization preparation and image acquisition scheme was developed to obtain high‐resolution brain images with optimal tissue contrast. The pulse sequence was derived from an optimization process using simulated annealing, without prior assumptions with regard to the number of radiofrequency (RF) pulses and flip angles. The resulting scheme combined two inversion pulses with the acquisition of three images with varying contrast. The combination of the three images allowed separation of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) based on __T__~1~, contrast. It also enabled the correction of small errors in the initial __T__~1~ estimates in postprocessing. The use of three‐dimensional (3D) sensitivity‐encoded (SENSE) echo‐planar imaging (EPI) for image acquisition made it possible to achieve a 1.15^3^ mm^3^ isotropic resolution within a scan time of 10 min 21 s. The cortical GM signal‐to‐noise ratio (SNR) in the calculated GM‐only image varied between 30 and 100. The novel technique was evaluated in combination with blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging (fMRI) on human subjects, and provided for excellent

Who reads Optimizing brain tissue contrast with EPI: A simulated annealing approach?

Author

Vasiliki N. Ikonomidou; Peter van Gelderen; Jacco A. de Zwart; Masaki Fukunaga; Jeff H. Duyn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2005

Language

EN

Field

Medicine (Health Sciences)