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Can I read A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects on EtoBox?
A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects by Margaret E. Olson; Mary G. Hornick; Ashley Stefanski; Haya R. Albanna; Alesia Gjoni; Griffin D. Hall; Peter C. Hart; Ibraheem M. Rajab; Lawrence A. Potempa is a Immunology and Microbiology article available to read on EtoBox.
What is A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects about?
C-reactive protein (CRP) is an acute phase, predominantly hepatically synthesized protein, secreted in response to cytokine signaling at sites of tissue injury or infection with the physiological function of acute pro-inflammatory response. Historically, CRP has been classified as a mediator of the innate immune system, acting as a pattern recognition receptor for phosphocholine-containing ligands. For decades, CRP was envisioned as a single, non-glycosylated, multi-subunit protein arranged non-covalently in cyclic symmetry around a central void. Over the past few years, however, CRP has been shown to exist in at least three distinct isoforms: 1.) a pentamer of five identical globular subunits (pCRP), 2.) a modified monomer (mCRP) resulting from a conformational change when subunits are dissociated from the pentamer, and 3.) a transitional isoform where the pentamer remains intact but is partially changed to express mCRP structural characteristics (referred to as pCRP\* or mCRP~m~). The conversion of pCRP into mCRP can occur spontaneously and is observed under commonly used experimental conditions. In careful consideration of experimental design used in published reports of __in vi
Who reads A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Margaret E. Olson; Mary G. Hornick; Ashley Stefanski; Haya R. Albanna; Alesia Gjoni; Griffin D. Hall; Peter C. Hart; Ibraheem M. Rajab; Lawrence A. Potempa
- Publisher
- Frontiers Media SA
- Published
- 2023
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)