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Can I read Magneto-mechanical Destruction of Cancer-associated Fibroblasts Using Ultra-small Iron Oxide Nanoparticles and Low Frequency Rotating Magnetic Fields† on EtoBox?
Magneto-mechanical Destruction of Cancer-associated Fibroblasts Using Ultra-small Iron Oxide Nanoparticles and Low Frequency Rotating Magnetic Fields† by Sara Lopez; Nicolas Hallali; Yoann Lalatonne; Arnaud Hillion; Joana C. Antunes; Nizar Serhan; Pascal Clerc; Daniel Fourmy; Laurence Motte; Julian Carrey; Véronique Gigoux is a Materials Science article available to read on EtoBox.
What is Magneto-mechanical Destruction of Cancer-associated Fibroblasts Using Ultra-small Iron Oxide Nanoparticles and Low Frequency Rotating Magnetic Fields† about?
The destruction of cells using the mechanical activation of magnetic nanoparticles with low-frequency magnetic fields constitutes a recent and interesting approach in cancer therapy. Here, we showed that superparamagnetic iron oxide nanoparticles as small as 6 nm were able to induce the death of pancreatic cancer-associated fibroblasts, chosen as a model. An exhaustive screening of the amplitude, frequency, and type (alternating __vs.__ rotating) of magnetic field demonstrated that the best efficacy was obtained for a rotating low-amplitude low-frequency magnetic field (1 Hz and 40 mT), reaching a 34% ratio in cell death induction; interestingly, the cell death was not maximized for the largest amplitudes of the magnetic field. State-of-the-art kinetic Monte-Carlo simulations able to calculate the torque undergone by assemblies of magnetic nanoparticles explained these features and were in agreement with cell death experiments. Simulations showed that the force generated by the nanoparticles once internalized inside the lysosome was around 3 pN, which is in principle not large enough to induce direct membrane disruption. Other biological mechanisms were explored to explain cell dea
Who reads Magneto-mechanical Destruction of Cancer-associated Fibroblasts Using Ultra-small Iron Oxide Nanoparticles and Low Frequency Rotating Magnetic Fields†?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Sara Lopez; Nicolas Hallali; Yoann Lalatonne; Arnaud Hillion; Joana C. Antunes; Nizar Serhan; Pascal Clerc; Daniel Fourmy; Laurence Motte; Julian Carrey; Véronique Gigoux
- Published
- 2022
- Language
- EN
- Field
- Materials Science (Physical Sciences)